Mitochondrial ageing and antiretroviral therapy exposure
نویسندگان
چکیده
منابع مشابه
Mitochondrial ageing and antiretroviral therapy exposure
Methods We have recruited adult HIV-infected patients, all aged 50 years or under. Subjects were stratified according to cumulative (lifetime) exposure to those NRTIs previously implicated in disruption of mtDNA replication. Proportional level of the age-associated mtDNA common deletion (CD) was measured by means of a novel real-time PCR assay. Based on these and prior observations from our gro...
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Susceptibility to peripheral neuropathy during antiretroviral therapy with nucleoside reverse-transcriptase inhibitors was previously associated with a European mitochondrial DNA (mtDNA) haplogroup among non-Hispanic white persons. To determine whether nucleoside reverse-transcriptase inhibitor-associated peripheral neuropathy was related to mtDNA variation in non-Hispanic black persons, we seq...
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In recent years, an association has been described between the use of protease inhibitors for antiretroviral therapy and the appearance of angiolipomas and lipomas, as well as with an increase in the number and size of those already present.1-3 A 40-year-old man consulted in 2005 for lesions that first appeared in 1998, and that had increased in number and size since then. Some were tender to p...
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ژورنال
عنوان ژورنال: Journal of the International AIDS Society
سال: 2010
ISSN: 1758-2652
DOI: 10.1186/1758-2652-13-s4-o28